The Sysdig agent instrumentation sits in the operating system, and is completely hypervisor-agnostic.
The agent supports environments with physical servers, hypervisors (e.g. VMWare), or containers. These environments can be located either on-premesis or cloud based (e.g. AWS, Rackspace, etc.) and be combined in any mix without issue. The agent is available in a native Linux installation or via a containerized installation.
Sysdig Monitor offers an online SaaS solution where we maintain the entire reporting infrastructure, and an on-premises solution if you wish to retain complete control of all resources.